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Description
Purified anti-FMRP. The gene encoding Fragile X mental retardation protein 1 (FMRP or FMR1), also known as premature ovarian failure 1 (POF1), contains multiple CGG sequence repeats that are positively correlated with impaired cognitive and reproductive function. FMRP may be involved in mRNA transport and synaptic protein synthesis. The gene that encodes FMRP is located in the X chromosome, and an abnormally large number of CGG repeats (200 - 1000 times) causes Fragile X syndrome due to inadequate amounts of FMRP, leading to severe learning deficiency and mental retardation.
Immunogen
This monoclonal antibody was raised against a recombinant protein isolated from baculovirus expressing mouse FMRP.
Other Names
Fragile X mental retardation protein 1, POF, FMRP, POF1, FRAXA