Recombinant SerRatia marcescens DNA-binding protein H-NS (hns)
Description
Purity > 90% as determined by SDS-PAGE. MW: 17.5kDa. Full Length of Mature Protein: 2-135aa. N-terminal 6xHis-tagged. Serratia marcescens. H-NS binds tightly to ds-DNA, increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its ability to bind to curved DNA sequences, which are found in regions upstream of a certain subset of promoters. It plays a role in the thermal control of pili production. It is subject to transcriptional auto-repression. It binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150 (By similarity).