If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Rabbit IgG polyclonal Picoband? antibody for Thyrotropin receptor(TSHR) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. TSHR (Thyroid-Stimulating Hormone Receptor), also called LGR3, is mapped to 14q31.1. The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TSH Receptor (244-277aa KGLEHLKELIARNTWTLKKLPLSLSFLHLTRADL), different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.