5 ug (trial size), 20 ug (trial size), 100 ug, 200 ug
Concentration
n/a
Applications
FACS, ICC, IF, IHC-P, P-ELISA, WB
Reviews / Ratings
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Description
Rabbit polyclonal antibody to caspase 3 is also known as apopain and whose expression can be detected in the tonsils and skeletal muscles but it is highly expressive in the spleen and kidney. It is found in the death-inducing signaling complex in plasma membrane. This protein is extensively involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp-|-Gly-217 bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain.
Immunogen
KLH conjugated synthetic peptide derived between 33178 amino acids of human Caspase 3