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Description
p38 MAPK (Thr180/Tyr182) Polyclonal Antibody. ? Target Background: p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation and other signals. p38 MAPK is relatively inactive in the non-phosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, ?, ?, ? and ?, which differ in their tissue expression and affinity for upstream activators and downstream effectors.When cells are exposed to tumor necrosis factor-?, interleukin-1, heat shock, or other activating sti
Immunogen
Synthetic phospholyrated peptide (KLH coupled) corresponding to residues around Thr180/Tyr182 of human p38 MAP kinase