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Description
Alexa Fluor? 594 anti-human VEGFR1. VEGF-R1, also known as Fms-related tyrosine kinase 1 (FLT-1), is type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases. ?Human VEGF-R1 is mainly expressed by endothelial cells, which plays central role in vasculogenesis, angiogenesis and lymphaniogenesis. VEGFR-1 is the only VEGFR present on the surface of monocytes, and it mediates a chemotactic response to VEGF-A and tissue factor induction. It also reported on placental trophoblast cells, osteoblasts, placental trophoblasts, renal mesangial cells, and some hematopoietic stem cells. VEGFR1 ?is regulated by PEDF, which effects its intracellular proteolysis rate. sVEGFR1 regulates the availability of VEGFA and is produced in the placenta under hypoxic conditions. The ligands of VEGF-R1 include VEGF-A, VEGF-B, and PIGF splice isoforms.