Recombinant Human Protein CYR61 protein (CYR61) (Active)
Description
Purity > 95% as determined by SDS-PAGE and HPLC. MW: 39.4kDa. Full Length of Mature Protein: 25-381aa. tag-Free. Homo sapiens (Human). Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
CCN family member 1, Insulin-like growth factor-binding protein 10, IBP-10, IGF-binding protein 10, IGFBP-10