20-175aa; Full Length. MW: 34kD. Purity >90% as determined by SDS-PAGE. Functional viral IL-10 homolog. Can bind to the human IL-10 receptor and compete with human IL-10 for binding sites. Requires both subunits of the human IL-10 receptor complex to induce signal transduction events and biological activities. IL-10 signaling pathway has several immunosuppressive activities that are exploited by the virus. Inhibits TLR-induced type I interferon production in host plasmacytoid dendritic cells.
Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.Chang W.L., Baumgarth N., Yu D., Barry P.A.J. Virol. 78:8720-8731(2004)