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Description
Purified anti-PIK3R2. Phosphoinositide-3-kinase (PI3 kinase) is a lipid kinase that plays a critical role in cell signaling through generation of phosphoinositides at the plasma membrane in response to growth factor and hormone stimulation. Activation of PI3K is essential for cell growth, migration, motility, and survival. PI3K is comprised of a catalytic subunit, p110, that harbors enzymatic activity and a regulatory subunit, p85, that promotes both p110 stability and inhibition of p85. Moreover, p85 recognizes phosphorylated growth factor receptors via 2 SH2 domains that bring the PI3K dimer to the plasma membrane and in closer proximity to its substrate. Two p85 isoforms, p85α and p85β, have been described. Elevated expression of PIK3R2 (p85β) has been described in breast and colon cancers and is associated with increased tumorigenesis.