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Description
Purified anti-p27Kip1. p27Kip1 (cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor p27) is a 27kD cyclin-dependent inhibitor. p27Kip1 is localized in the nucleus and cytoplasm (phospho-specific). This protein functions in G1 arrest and binds and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2. p27Kip1 mediates TGF β-induced G1 arrest and regulates cell motility. This kinase has also been implicated in translational control. Akt phosphorylation causes p27 Kip1 export to cytoplasm; p27 Kip1 has also been shown to be ubiquitinated. p27 Kip1 has been shown to interact with NUP50, Skp2, and PKB/Akt. The Poly6029 antibody recognizes the C-terminal region of human p27Kip1 and has been shown to be useful for Western blotting.
Immunogen
Peptide derived from the carboxy terminus of human p27