A RAF inhibitor (IC50s = 2.4, 140, and 91 nM for mutant B-RAFV600E, wild-type B-RAF, and C-RAF, respectively); inhibits phosphorylation of ERK in A375 and COLO 829 cells (IC50s = 16 and 18 nM, respectively); does not induce paradoxical pERK activation and proliferation of cancer cell lines (EC50s = >200 μM); inhibits tumor growth in a mouse COLO 205 colon cancer xenograft model ,