Recombinant Human Probable ATP-dependent RNA helicase DDX58
Description
1-430aa; Partial. MW: 53.3kD. Purity >90% as determined by SDS-PAGE. Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at
RIG-I, a human homolog gene of RNA helicase, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell.Sun Y.-W.Thesis (1997), Shanghai Institute of Hematology, ChinaRetinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2.Imaizumi T., Aratani S., Nakajima T., Carlson M., Matsumiya T., Tanji K., Ookawa K., Yoshida H., Tsuchida S., McIntyre T.M., Prescott S.M., Zimmerman G.A., Satoh K.Biochem. Biophys. Res. Commun. 2