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Description
Rabbit Anti-AKT1S1 (phospho T246) Recombinant Antibody (BA0306). This product is a rabbit antibody that recognizes AKT1S1 (phospho T246). The antibody BA0306 can be used for immunoassay techniques such as: WB, IP. AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein when phosphorylated. Akt1s1, which they called Pras40, from rat hepatoma cells. By EST database analysis, they identified mouse and human PRAS40. The deduced 256-amino acid human protein contains 2 N-terminal proline-rich regions and a C-terminal AKT phosphorylation site, thr246, that is conserved in rat and mouse. mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for
Immunogen
Synthetic phosphopeptide from residues surrounding Threonine 246 of Human PRAS40