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Description
PE anti-human LOX-1. Lectin-like oxidized LDL receptor 1 (LOX-1), also known as CLEC8A, is a 31 kD, single pass, type II, transmembrane protein, member of the C-type lectin superfamily. LOX-1 is a scavenger receptor involved in endocytosis, phagocytosis, and cytokine production. LOX-1 is expressed by endothelial cells, smooth muscle cells, platelets, fibroblasts, and macrophages, and is upregulated by inflammatory and oxidative stimuli. LOX-1 recognized numerous ligands including lipoproteins, apoptotic cells heat shock proteins, C-reactive protein, and oxidized LDL. LOX-1 is implicated in atherosclerosis and vascular inflammation.