Purity > 90% as determined by SDS-PAGE. MW: 28.5kDa. Extracellular Domain: 44-261aa. N-terminal 6xHis-tagged. Macaca mulatta (Rhesus macaque). Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Tumor necrosis factor ligand superfamily member 5; CD_antigen: CD154