Purity > 90% as determined by SDS-PAGE. MW: 57.4kDa. Full Length of Mature Protein: 20-497aa. N-terminal 6xHis-tagged. Rattus norvegicus (Rat). Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.