Recombinant Human Integrin-linked protein kinase (ILK), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 30kDa. Partial: 1-228aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.