Recombinant Human Interferon-induced transmembrane protein 1 (IFITM1), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 31kDa. Extracellular Domain: 1-36AA. N-terminal GST-tagged. Homo sapiens (Human). IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Dispanin subfamily A member 2a; DSPA2aInterferon-induced protein 17Interferon-inducible protein 9-27Leu-13 antigen; CD225