A pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, Trka and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively); exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro and diverse xenografts in mice