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Description
Rabbit IgG polyclonal antibody for TNF receptor-associated factor 3(TRAF3) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. TRAF3(TNF Receptor-Associated Factor 3), also called LAP1, CAP1, CRAF1 or CD40BP, is a protein that in humans is encoded by the TRAF3 gene. The protein encoded by this gene is a member of the TNF receptor(TNFR) associated factor(TRAF) protein family. Gross(2012) mapped the TRAF3 gene to chromosome 14q32.32 based on an alignment of the TRAF3 sequence with the genomic sequence(GRCh37). Dadgostar et al.(2003) determined that the coiled-coil domain of mouse T3jam interacted with the isoleucine zipper domain of Traf3. Oganesyan et al.(2006) demonstrated that cells lacking TRAF3 are defective in type I interferon responses activated by several different Toll-like receptors.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human TRAF3(387-403aa RHDQMLSVHDIRLADMD), identical to the related rat and mouse sequences.