Mouse TNFRSF17-Fc Chimera is a type I attached membrane protein of 185 amino acids, which possesses a conserved motif of six cysteines in the N-terminal. It is consistent with the formation of a cysteine repeat motif found in the extracellular domain of TNFRs, and is 62% identical to the human receptor. The overexpression of TNFRSF17-Fc Chimera in 293E cells activates NF-κB, Elk-1, the c-Jun N-terminal kinase, and the p38 mitogen-activated protein kinase. After its association with TNF Receptor-Associated Factor (TRAF) 1, TRAF2, and TRAF3. Soluble forms of TACI (TNFRSF13B) and TNFRSF17-Fc Chimera bind to BAFF (TNFSFL13B) and APRIL (TNFSFL13A). The interaction of TNFRSF17-Fc Chimera to APRIL has higher affinity than the TNFRSF17-BAFF interaction. Analysis of BCMA knockout mice (BCMA?/?) showed no differences in the steady-state frequencies or composition of peripheral B cell subsets (immature, marginal zone, follicular, B1). BCMA expression is upregulated on PBMCs from mice that develop a Sjogren’s-like syndrome, patients with Sjogren’s syndrome, with rheumatoid arthritis, and on B cells from SLE patients.
Size
100 μg
Concentration
n/a
Applications
BA
Other Names
B cell maturation antigen (BCMA), tumor necrosis factor receptor superfamily member 17, CD269