Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2000
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Description
MAPKBP1 Polyclonal Antibody. MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-β-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFκB (nuclear factor κ-B) activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises
Immunogen
n/a
Other Names
Mitogen-activated protein kinase-binding protein 1; JNK-binding protein 1; JNKBP-1; JNKBP1; KIAA0596