Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis.{14779} 2-cyano-Pyrimidine is a cathepsin K inhibitor whose basic structure and derivatives are being studied for the treatment of osteoporosis. 2-cyano-Pyrimidine has an IC50 value of 170 nM for inhibition of cathepsin K.{14799}
Size
5 g
Concentration
n/a
Applications
n/a
Other Names
cathepsin K osteoporosis osteoclasts lysosomes cysteine proteases