Recombinant Human Notch-3-Fc Chimera (carrier-free)
Description
Human Notch-3 is a large type I transmembrane glycoprotein that is involved in cell fate specification, differentiation, and tissue patterning.? Notch has two distinct domains, an extracellular domain (NECD) responsible for the interaction with the ligands and an intracellular domain (NICD) responsible for signal transduction.? Human NECD (amino acid 19-526) shows 91% amino acid sequence identity with mouse and rat NECD.? There are five Notch ligands (DLL1, DLL3, DLL4, Jagged-1 and Jagged-2) and four Notch receptors (Notch-1 to Notch-4) in mammals.? Interactions of Notch receptors with membrane bound ligands result in sequential proteolysis by ADAM (disintegrin metalloprotease) and then by presenilin/gamma secretase, resulting in the shedding of NECD and the generation of soluble NICD signaling fragments. The NICD translocates to the nucleus and interacts with transcriptional factors to promote the transcription of target genes.? Notch-3 interaction with its ligands regulate a number of biological functions such as differentiation, proliferation, angiogenesis, apoptosis and stem cell renewal.? Mutations in Notch-3 in humans is associated with an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), IMF2 (infantile myofibromatosis-2), and LMS (lateral meningocele syndrome).
Size
25 μg
Concentration
n/a
Applications
BA
Other Names
Notch drosophila homolog of 3, Notch3, Neurogenic locus notch homolog protein 3