IL-22 is belonging to IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Membersof this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Producedby T lymphocytes and dendritic cells, IL-10 contributes to the inflammatory response in vivo. IL-22 signals through CRF2-4 andIL-22. It along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays arole in the coordinated response of both adaptive and innate immune systems. Recombinant rat Interleukin-22 contains 146amino acids and it has approximately 79 % and 92 % amino acid sequence identity with human and murine IL-22. MW: 16.6 kDa. Purity > 97 % by SDS-PAGE and HPLC analyses
Size
2 ug, 10 ug, 1 mg, 100 ug, 250 ug, 500 ug
Concentration
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.