Interleukin-33 (IL-33), also known as NF-HEV and DVS 27, is a cytokine belonging to the IL-1 superfamily. It is also aproinflammatory protein that may regulate gene transcription and it induces helper T cells, mast cells, eosinophils and basophilsto produce type 2 cytokines. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathologicalchanges observed in mucosal organs following administration of IL-33. IL-33 is constitutively expressed in smooth muscle andairway epithelia and it binds to a high-affinity receptor family member ST2. In vivo administration of mature IL-33 promotesincreased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues.Recombinant rat IL-3 contains 156 amino acid residues and it shares 59 % a.a. and 90 % sequence identity with human andmurine IL-33. MW: 17.4 kDa. Purity > 95 % by SDS-PAGE and HPLC analyses
Size
2 ug, 10 ug, 1 mg, 100 ug, 250 ug, 500 ug
Concentration
Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris, 300 mM NaCl, pH 8.5, 3mM beta -mercaptoethanol.