Recombinant Human BMPR1B/ALK-6-Fc Chimera (carrier-free)
Description
The transforming growth factor- (TGF ) superfamily control a big number of biological responses and play a prominent role during embryonic development, regulation of cell growth, differentiation, and apoptosis. 40 distinct TGF members have been identified in vertebrates and they are generally divided into two branches, the TGF /activin/nodals and the bone morphogenetic proteins (BMPs). The Bmp family regulates embryogenesis and postnatal tissue homeostasis. Bmp proteins signal through serine/threonine kinase receptors known as type I and type II receptors. Four type I receptors: Bmpr1a (Alk3), Bmpr1b (Alk6), Acvrl1 (Alk1), and Acvr1 (Alk2), and three type II receptors: Bmpr2 (BMPRII), Acvr2a (ActRIIA) and Acvr2b (ActRIIB) mediate Bmp signaling. After activation, the type I receptors activate receptor Smads (Smad1, 5, 8) through phosphorylation. Deletion of Bmpr1b induces osteopenia in 8-week-old male mice, and Bmpr1b mutant bone marrow mesenchymal progenitors show compromised differentiation in vitro. Some luminal breast tumors possible seem to be the result of an amplified response of mammary stem cells to imbalance BMP2 levels and BMPR1B-mediated signaling. In addition, SNPs of BMPR1B have been suggested to correlate with endometriosis development.
Size
10 μg
Concentration
n/a
Applications
BA
Other Names
Bone Morphogenetic Protein Receptor Type 1B (BMPR1B), Activin Receptor-Like Kinase 6 (ALK6), BMP Type-1B Receptor.