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Description
Mouse IgG monoclonal Picoband? antibody for CD2AP detection. Tested with WB, IHC-P, FCM in Human;Mouse;Rat. No cross reactivity with other proteins. CD2-associated protein is a protein that in humans is encoded by the CD2AP gene. This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
Immunogen
E. coli-derived human CD2AP recombinant protein (Position: K253-K337).
Other Names
CD2-associated protein; Adapter protein CMS; Cas ligand with multiple SH3 domains; CD2AP