N-terminal Xaa-Pro-Lys N-methyltransferase1 isoform a, 1-223aa, Human, His tag, E.coli
Description
Purity: > 95% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 0.15M NaCl, 10% glycerol. NTMT1 also known as N-terminal Xaa-Pro-Lys N-methyltrasferase1 isoform a. NTMT1 is catalyzes the transfer of the methyl group from the S-adenosyl-l-methionine to the protein alpha-amine, resulting in formation of S-adenosyl-l-homocysteine and alpha-N-methylated proteins. NTMT1 is an interesting potential anticancer target because it is overexpressed in gastrointestinal cancers and plays an important role in cell mitosis. Recombinant human NTMT1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.