Recombinant Human Negative elongation factor B (NELFB), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 48.9kDa. Partial: 8-199aa. N-terminal GST-tagged. Homo sapiens (Human). Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding.