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Description
Alexa Fluor? 594 anti-E1 Ubiquitin Activating Enzyme. The proteasomal pathway of protein degradation involves two discrete steps: ubiquitination and degradation. Aside from proteasomal degradation, ubiquitination also plays an important role in transcriptional regulation, protein trafficking including endocytosis and lysosomal targeting, and the activation of kinases involved in signaling processes. Ubiquitination is carried out in three main steps: activation, conjugation, and ligation. E1 Ubiquitin Activating Enzyme (UBE1) initiates the cascade of conjugation by activating their respective modifiers. It is highly conserved in human, yeast, and plants. The gene for E1 Ubiquitin activating enzyme complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair.