Flow Cytometry (FC), Immunofluorescence Microscopy (IF), IP
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Description
Purified anti-CD49D. CD49d is a 150 kD glycoprotein, also known as integrin α4 or VLA-4 α chain. It is expressed as a heterodimer with either of two β chains, β1 or β7. The α4β1 integrin (also known as VLA-4, CD49d/CD29) is expressed on peripheral T and B lymphocytes, thymocytes, and monocytes, while the α4β7 integrin (also known as LPAM-1) is expressed on peripheral lymphocytes. The α4β1 and α4β7 integrins mediate cell-cell and cell-matrix interactions by interacting with the ligands CD106 (VCAM-1), MAdCAM-1, and fibronectin. Soluble P4C2 antibody can partially inhibit in vitro binding of VCAM-1 and mast cells to fibronectin and inhibit mast cell degranulation. Immobilized P4C2 antibody can enhance mast cell degranulation in vitro.
Immunogen
The P4C2 monoclonal antibody was generated against human Molt 4 T-lymphocytes. It was subsequently purified using protein G.
Other Names
Integrin alpha-4, integrin alpha-IV, VLA-4 subunit alpha, integrin alpha-4 subunit, CD49 antigen-like family member D, antigen CD49D, alpha-4 subunit of VLA-4 receptor, very late activation protein 4 receptor, alpha 4 subunit, MMS-492P-100