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Description
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the two-electron reduction of quinones and their derivatives . This enzyme protects cells against redox cycling and oxidative stress . The expression of NQO1 is increased in liver, colon and breast tumors and non-small cell lung cancer (NSCLC) compared with the normal tissues . Moreover, expression levels are also elevated in developing tumors, suggesting a role for NQ01 in the prevention of tumor development . Studies on NQO1 knockout mice suggest that the lack of NQO1 enzymatic activity changes intracellular redox states resulting in a reduction in apoptosis, which in turns leads to myeloid hyperplasia of bone marrow . Synonyms: DHQU, DIA4, DTD, NMOR1, NMORI, QR1