A potent inhibitor of SPHK1 (IC50 = 2 nM); inhibits S1P binding to human recombinant SPHK1 (Ki = 3.6 nM); selective for SPHK1 over SPHK2 (IC50 = 356 nM) as well as a panel of protein and lipid kinases and S1P receptors at 10 μM; inhibits the formation of S1P in 1483 cells and human whole blood (EC50s = 8.4 and 26.7 nM, respectively); prevents sickling, hemolysis, and inflammation in a transgenic mouse model of sickle cell disease
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
1415562-83-2 biochemical inhibitor kinase protein signal transduction intracellular signaling cancer vascular disease inhibit inhibition PF543 PF 543 SK1 SK2 sphingosine lipid receptor phosphorylation cell blood sickle sickling hemolysis inflammation