A vitamin K2 analog; increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells; increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats at 1 μM; inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification at 100 μg/g diet; increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss