2-154aa, Full Length of Mature Protein. MW: 17,458 Da. Purity >85% (SDS-PAGE). This protein contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2AMEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).