Recombinant Human Polypyrimidine tract-binding protein 1 (PTBP1)
Description
Purity > 85% as determined by SDS-PAGE. MW: 63.1kDa. Full Length of Isoform: 1-557aa. N-terminal 10xHis-tagged. Homo sapiens (Human). Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site and stimulates the IRES-mediated translation.