LRH-1, also called NR5A2, is a nuclear receptor that is an essential regulator of gene transcription, critical for early cellular development and imperative for the proper functions of the liver, pancreas, and intestines during the adult life. In the liver, LRH-1 regulates the expression of key genes involved in bile acid synthesis, cholesterol homeostasis and transport. Because of its decisive role in cell differentiation, LRH-1 is linked to multiple developmental pathways. LRH-1 activity is linked to breast and endometrial cancers as well as intestinal tumors and cancer of the pancreas.
Size
96 well
Concentration
n/a
Applications
n/a
Other Names
Liver Receptor Homolog-1|NR5A2|Nuclear Receptor Subfamily 5, Group A, Member 2