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Description
The molecular complex of Class I antigen consists of a membrane-embedded, glycosylated heavy chain in tight but noncovalent association with b2-microglobulin . HLA class I molecules are heterodimers made of a 45 kDa a chain with three extracellular domains non-covalently associated with the invariant 12 kDa b2-microglobulin and are expressed on all nucleated cells. Ploegh H.L., et al., 1981, Cell, 24,287- Monoclonal antibodies specific to human b2-microglobulin induce myeloma and leukaemia cell lines apoptosis in vitro. These same antibodies were also therapeutic in vivo, in mouse models of haematological tumor cells. Yang J. et al.,2006, Cancer Cell, 10, 295-;Shi C. et al., 2009, Drug Discovery, 14, 25-