Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4)
Clone
RYNmCTLA-4
Host Species
Rat
Reactive Species
mouse
Isotype
n/a
Format
unconjugated
Size
0.5 mg
Concentration
n/a
Applications
n/a
Reviews / Ratings
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Description
CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseasesSynonyms: GSE, CD152, IDDM12, CELIAC3, CTLA-4