Immunohistochemistry (Paraffin): 1:250, Western Blot: 1:500-1:2000
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Description
CHP1 Monoclonal Antibody (OTI1D11). Chp1 a chromodomain protein associates with the S. pombe mating type locus and telomeres. Chp1 localization to heterochromatin depends on its chromodomain and the C-terminal domain of the protein. Chp1 and centromeric siRNAs are components of the RITS (RNA-induced initiation of transcriptional gene silencing) complex. The association of RITS with centromeres is linked to Dicer activity, which is required to cleave centromeric transcripts to produce short interfering RNAs that actively recruit components of heterochromatin to centromeres.
Immunogen
n/a
Other Names
SLC9A1BP, SLC9A1 binding protein, calcineurin B homolog, calcineurin homologous protein, calcium-binding protein CHP, calcium-binding protein p22