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Description
Rabbit IgG polyclonal antibody for Endothelial transcription factor GATA-2(GATA2) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. GATA2(GATA binding protein 2) is a human gene which makes a protein called GATA binding protein 2 - a transcription factor. The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells. Ciciotte et al.(1997)mapped the mouse Gata2 gene to chromosome 6 by study of DNA from an interspecific backcross panel. They pointed out that the human gene had been mapped to chromosome 3 by Dorfman et al.(1992) using DNA from a panel of 12 rodent/human hybrids containing various human chromosomes and applying Southern blot analysis. By exon trapping using a PAC contig spanning a breakpoint region associated with myeloid leukemia, Wieser et al.(2000) mapped the GATA2 gene to chromosome 3q21. GATA2 is transcribed from telomere to centromere. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human GATA2(46-60aa DVFFNHLDSQGNPYY), identical to the related rat and mouse sequences.
Other Names
Endothelial transcription factor GATA-2;GATA-binding protein 2;GATA2;