A reversible inhibitor of the auto and transphosphorylation kinase activity of the ErbB receptor tyrosine kinase superfamily: EGFR (IC50 = 8 μM), ErbB-2 (IC50 = 49 nM), ErbB3, and ErbB4 (IC50 = 52 nM); induces G1 cell cycle arrest in MCF10A breast cancer cells
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
PD158780 inhibitor erbB receptor tyrosine kinase EGFR erbB2 HER2 heregulin-β1 erbB3 erbB4 antiproliferation cancer inhibit biochemical protein signal transduction