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Description
SNCA belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy. Synonyms: Monoclonal Synuclein Alpha antibody, Anti-Synuclein Alpha antibody, MGC110988 antibody, NACP antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, Non A4 Component Of Amyloid Precursor antibody, SNCA antibody.
Immunogen
alpha Synuclein antibody was raised in Mouse using a purified recombinant fragment of SNCA expressed in E. coli as the immunogen.