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Description
Mouse Anti-LAT Recombinant Antibody (LAT.10-17). Provided herein is a Mouse monoclonal antibody, which binds to Linker For Activation Of T Cells (LAT). The antibody can be used for immunoassay techniques, such as WB, FC, IHC-P, FC. LAT is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and plays a role as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants