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Description
Mouse Anti-ADAM17 Recombinant Antibody (BA0391). This product is a mouse antibody that recognizes ADAM17. The antibody BA0391 can be used for immunoassay techniques such as: FC, IF, IHC-P, WB. Black et al. (1997) cloned a human cDNA encoding ADAM17, which they called TACE. The gene encodes an 824-amino acid polypeptide containing the features of the ADAM family: a secretory signal sequence, a disintegrin domain, and a metalloprotease domain. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha (TNFA; 191160) to its mature form. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound p