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Description
Rabbit Anti-SOST Recombinant Antibody (CBXS-4250). This product is a rabbit antibody that recognizes SOST. The antibody CBXS-4250 can be used for immunoassay techniques such as: ELISA, IP. Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.