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Description
The CD29 antigen, also known as the β-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the β integrin, forms a lymphocyte homing receptor for Peyer's patch, binding tothe mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3-dependent CD4+ T-lymphocyte activation via its interaction with fibronectin. CD49d (Anti-VLA-α-4) recognizes the 150-kilodalton (kd) α-chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules. VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of α and β subunits and is involved in cell-cell and cell-extracellular matrix interactions. The β-chain of the VLA-4 complex is the CD29 antigen, a 130-kd glycoprotein.
Immunogen
Tissue / cell preparation (JM leukemia line).
Other Names
CD49d; Alpha-4 integrin chain; VLA-4 alpha chain; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; Integrin alpha-4; CD antigen CD49d; Integrin α4; CD49d (Integrin alpha 4); VLA alpha-4 chain (Lymphocyte Homing Receptor); MAB TO CD49D; ITGA4