Recombinant Human Rab proteins geranylgeranyltransferase component A 1 (CHM)
Description
Purity > 90% as determined by SDS-PAGE. MW: 77.5kDa. Full Length: 1-653aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Choroideremia protein; Rab escort protein 1; Short name:REP-1; TCD protein