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Description
C1 component of human complement is a complex of three glycoproteins: C1q, C1r and C1s. C1r has a molecular weight of 83,000 and is present in plasma in an average concentration of 50mg/mL, either as a complex with C1q and C1s or in the absence of C1q as a tetramer with C1s. The subcomponents of the C1 complex are responsible for the initiation of the classical pathway of complement activation.Synonyms: Complement 1r, Complement C1r, Complement C1r subcomponent, Complement component 1 subcomponent r
Immunogen
The subunit C1r is isolated as a homogenous protein for use in antiserum production. Freund's complete adjuvant is used in the first step of the immunization.